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3.3.1 Background Anxiety disorders represent a group of persistent neuropsychiatric conditions affecting approximately 4.05% of the global population, with prevalence rising by over 55% since 1990 (Javaid et al., 2023)

and one of the largest globally

This peri-ovulation profile was originally planned to follow the changes of Se-GSH-Px during the preovulatory phase of the estrus cycle in sows

Patients require structured monitoring including blood pressure, heart rate, mental health status, and renal function, with immediate reporting of seizure warning signs or psychiatric changes through established healthcare channels

In 2025, it was also approved to treat chronic kidney disease in patients with Type 2 diabetes